Tigecycline dosing is critical in preventing tigecycline resistance because relative resistance is, in part, concentration dependent
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چکیده
منابع مشابه
Tigecycline Susceptibility and the Role of Efflux Pumps in Tigecycline Resistance in KPC-Producing Klebsiella pneumoniae
KPC-producing Klebsiella pneumoniae isolates have emerged as important pathogens of nosocomial infections, and tigecycline is one of the antibiotics recommended for severe infections caused by KPC-producing K. pneumoniae. To identify the susceptibility profile of KPC-producing K. pneumoniae to tigecycline and investigate the role of efflux pumps in tigecycline resistance, a total of 215 KPC-pro...
متن کاملPotential of Tetracycline Resistance Proteins To Evolve Tigecycline Resistance.
Tigecycline is a glycylcycline antibiotic active against multidrug-resistant bacterial pathogens. The objectives of our study were to examine the potential of the Tet(A), Tet(K), Tet(M), and Tet(X) tetracycline resistance proteins to acquire mutations causing tigecycline resistance and to determine how this affects resistance to earlier classes of tetracyclines. Mutations in all four tet genes ...
متن کاملHigh tigecycline resistance in multidrug-resistant Acinetobacter baumannii.
OBJECTIVES Multidrug-resistant (MDR) Acinetobacter baumannii is increasing in our hospital and worldwide, raising the necessity of finding effective therapies. We aimed to evaluate the in vitro activity of tigecycline against MDR A. baumannii clones isolated before tigecycline was used in our institution. METHODS Eighty-two unique patient clinical isolates of multidrug-resistant A. baumannii ...
متن کاملEvolution and Mechanisms of Tigecycline Resistance in Escherichia coli
Linkevičius, M. 2015. Evolution and Mechanisms of Tigecycline Resistance in Escherichia coli. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1121. 58 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9285-4. Antibiotic resistance is an ongoing global medical crisis and we are in great need of new antibacterial agents to combat rapidly emerging r...
متن کاملRoles of Salmonella multidrug efflux pumps in tigecycline resistance.
OBJECTIVES salmonella enterica strains exhibiting decreased susceptibility to tigecycline have been reported. In this study, we sought to elucidate the roles of Salmonella multidrug efflux pumps and AcrAB regulators in tigecycline resistance. METHODS we examined the involvement of multidrug efflux pumps and AcrAB regulators in resistance to tigecycline and other glycylcyclines by determining ...
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ژورنال
عنوان ژورنال: Clinical Microbiology and Infection
سال: 2015
ISSN: 1198-743X
DOI: 10.1016/j.cmi.2015.01.002